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SYNERGISTIC EFFECT IN VIRAL‐BACTERIAL INFECTION
Author(s) -
Degré Miklos
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb02140.x
Subject(s) - sendai virus , in vivo , respiratory tract , respiratory system , in vitro , microbiology and biotechnology , virus , biology , nasal administration , organ culture , lung , inoculation , virology , bacteria , immunology , medicine , anatomy , biochemistry , genetics
The role of the tracheal ciliary activity in the host defence against bacterial respiratory infections was studied. In vivo infection of the mouse and in vitro infection of the mouse trachea organ cultures with parainfluenza 1, Sendai virus resulted in a patchy inhibition of ciliary activity. Lidocain chloride also inhibited reversibely the ciliary activity of organ culture systems in concentrations from 0.3 to 2 mg per ml medium. The same concentration had no effect on the phagocytic ability of alveolar macrophages. Intranasally inoculated Hemophilus influenzae were eliminated at a slower rate from the lungs of Lidocain treated mice than from normal animals, during the initial phase of infection. Slightly more mice died following H. influenzae infection after Lidocain treatment than without it, but the difference was not significant. The data support the concept that Sendai virus infection results in a reduced ciliary activity in the trachea, which again results in a delayed elimination of bacteria from the lungs.