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HEPATIC CHANGES IN DOGS AND RATS INDUCED BY XYLIDINE ISOMERS
Author(s) -
Magnusson Göran,
Bodin NilsOlov,
Hansson Eskii.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb01866.x
Subject(s) - medicine , endocrinology , fatty liver , chemistry , disease
The effect of the xylidine isomers 2, 4‐, 2, 5‐, and 2, 6‐xylidine on the liver arid kidneys of dogs and rats was studied. The dogs received oral doses of 2, 10, and 50 mg/kg and the rats 20, 100, and 500–700 mg/kg daily for 4 weeks. The xylidine isomers affected the liver but produced different hepatic changes in the dog and the rat. In the dog all 3 isomers induced a fatty degeneration of the liver. In the rat the 3 isomers caused a hepatomegaly mostly with a normal appearance of the liver cells. The enlargement of the liver was greatest for the 2, 4‐isomer and least for the 2, 6‐isomer. No renal lesions were found in any of the dogs or rats at any dose level.