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STUDIES OF THE GOITROGENIC AND ONCOGENIC EFFECT OF METHYLTHIOURACIL IN C 3 H MICE
Author(s) -
Jemeg B.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb01856.x
Subject(s) - methylthiouracil , medicine , thyroid , thiouracil , endocrinology , endogeny , chemistry , biology
Methylthiouracil (4‐Methyl‐2‐thiouracil: MTU) had a strong goitrogenic effect in C3H mice. Metabolic studies showed a significantly higher consumption of oxygen in thyroid gland tissue after treatment with MTU. Malignant changes were not observed. The serum of MTU and Thycapzol treated mice showed a higher capacity to bind T3—indicating a lower production of endogenous T4.