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DNA‐SYNTHESIS OF LYMPHOCYTES IN REGENERATING LIVER
Author(s) -
Fichtelius K. E.,
Kullgren B.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb01842.x
Subject(s) - dna synthesis , thymidine , dna , liver regeneration , lymph , biology , regeneration (biology) , lymphocyte , immunology , microbiology and biotechnology , pathology , medicine , biochemistry
There are numerous lymphocytes within the liver. It seems as if part of the recirculation of lymphocytes takes place via the liver itself and its lymph. The functional significance of the lymphocytes of the liver is unknown. The general aim of the present investigations was to gain some more information about the liver lymphocytes. The particular question asked was: Are lymphocytes within the liver stimulated to proliferate simultaneously with the liver cells during liver regeneration? Liver regeneration was induced with C Cl 4 in mice and DNA synthesis was studied with the aid of H 3 ‐thymidine labelling and autoradiography. The question could be answered affirmatively: Yes, the lymphocytes were stimulated to DNA synthesis either by a humoral factor at a distance, or in situ. The functional significance of the findings are discussed.