Premium
THE TRANSPLANTED RABBIT HEART. HISTOLOGICAL, IMMUNOFLUORESCENT AND ELECTROCARDIOGRAPHIC CHANGES
Author(s) -
Heron Iver
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb01834.x
Subject(s) - sarcolemma , infiltration (hvac) , pathology , mononuclear cell infiltration , globulin , rabbit (cipher) , peripheral blood mononuclear cell , cellular infiltration , edema , biology , anatomy , myocyte , medicine , immunology , inflammation , endocrinology , in vitro , biochemistry , statistics , physics , mathematics , thermodynamics
The morphological changes have been studied in 35 ectopically allotransplanted rabbit hearts. The grafts survived rejection for an average of 9.9 days in unmodified recipients and permitted serial biopsies beeing taken. Generalized mononuclear cell infiltration of the myocardium, interstitial oedema, endothelial oedema and proliferation and generalized myo‐cardial damage were the most prominent histological changes at rejection. A very small number of the infiltrating cells contained cytoplasmatic 7‐globulins. 7‐globulins were traced to the sarcolemma and heavy deposits could be seen intracellularly in degenerating myo‐cardial cells. Electrocardiograms showed that decline in voltage was the most reliable indication of impending cardiac rejection.