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ACCELERATION OF CASEIN INDUCED AMYLOIDOSIS IN MICE BY IMMUNOSUPPRESSIVE AGENTS
Author(s) -
Hardt Finn
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb00515.x
Subject(s) - amyloidosis , casein , immune system , pharmacology , medicine , immunology , chemistry , endocrinology , biochemistry
The effect of various immunosuppressive agents on the experimental mice amyloidosis has been examined. The mice were pretreated with 21 injections casein, on day 1, 3 and 5 after this treatment 12 immunosuppressive agents were applied to 12 groups of mice in dosis corresponding to LD 10 . All drugs applied accelerated the amyloidosis, even they differ in metabolic blocking potencies. The results seem to indicate that any interference with the immune apparatus of the mice favours the development of amyloidosis.