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Correlation between Infiltration of Mononuclear Cells And Production of Connective tissue in acute Hypertensive Vascular Disease
Author(s) -
Olsen Finn
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1971.tb00507.x
Subject(s) - connective tissue , infiltration (hvac) , pathology , peripheral blood mononuclear cell , chemistry , cytoplasm , fibroblast , medicine , materials science , biochemistry , in vitro , composite material
Damaged mesenteric arterioles from rats made hypertensive with intravenous injections of angiotensin showed a production of Van Gieson positive connective tissue which was proportional to the infiltration of mononuclear cells (lymphocytes and monocytes). Rats treated with antithymocyte serum before hypertensive damage of the arterioles showed no or only a very sparse cellular reaction and corresponding to this decreased cellular reaction no production of connective tissue fibrils was observed. As some fibroblast‐like cells contained carbon particles in their cytoplasm it is highly probable that they were transformed lymphocytes and/or monocytes, which had phagocytized carbon particles from the hypertensively damaged arterioles.