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REACTION OF STAPHYLOCOCCAL PROTEIN A WITH RABBIT IMMUNOGLOBULINS
Author(s) -
McDowell Graham,
Grov Arne,
Oeding Per
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb00113.x
Subject(s) - protein a , protein a/g , staphylococcus aureus , antigen , antibody , protein g , chemistry , rabbit (cipher) , strain (injury) , staphylococcus , microbiology and biotechnology , biology , biochemistry , immunology , bacteria , recombinant dna , fusion protein , anatomy , genetics , statistics , mathematics , gene
Results are presented to show that protein A from Staphylococcus aureus strain Cowan I elicits the synthesis of rabbit IgG which reacts with protein A through the Fab‐region. IgM from an anti‐protein A serum obtained 9 days after first injection of antigen appeared to react with crude protein A. It was also found that protein A and protein B are antigenic‐ally similar. In addition protein A contains distinctive determinants which appear to be responsible for the binding of protein A to the Fc‐region of IgG.