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CELLULAR AND HUMORAL ANTIBODY PRODUCTION AGAINST SHEEP ERYTHROCYTES IN AKR MICE
Author(s) -
Aasted Bent,
Rubin Bent,
Spärck J. V.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb00110.x
Subject(s) - antiserum , antibody , antigen , antibody response , immunology , chemistry , microbiology and biotechnology , biology , andrology , medicine
Mice were injected with a low or a high dose of sheep red blood cells (SRBC) followed by the injection 1 or 2 days later of varying quantities of anti‐SRBC antiserum. The effect of the passively administered antiserum on the primary and the secondary antibody response was studied. It was found that a low dose of antigen was unaffected by antiserum treatment and initiated a normal primary response, whereas a high antigen dose was greatly affected by antiserum treatment in the primary response. Both 19S and 7S memory could be more or less inhibited by passive antiserum treatment, dependent on the quantity of antiserum injected. Evidence for a 7S regulating effect on the 19S antibody synthesis is presented. The results are! discussed on the basis of the “cell selection by antigen” hypothesis and a central and peripheral inhibiting effect of passive antiserum.