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CELLULAR AND HUMORAL ANTIBODY PRODUCTION AGAINST SHEEP ERYTHROCYTES IN AKR MICE
Author(s) -
Rubin Bent
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb00065.x
Subject(s) - immune system , antibody , stimulation , antibody response , primary and secondary antibodies , antigen , immunology , medicine , endocrinology , biology
The primary immune response and the immunological memory have been studied in four groups of AKR mice using the haemolytic plaque assay. Two groups of mice, I and III, were given 4.10 6 and 4.10 8 SRBC, respectively; two other groups, II and IV, received additional 10 mg 6‐mercaptopurin (6MP)/kg body weight for 7 days. The primary 19S and 7S cellular antibody response in group III was 7—100 times greater than that in group I. The 6MP treatment depressed the primary immune response. The depression was greater in the mice stimulated with the lower antigen dose (group II). Ten days after the first stimulation, all four groups of mice were given 4.10 8 SRBC. Group I showed a marked immunological memory, whereas group III showed a secondary antibody response lower than the primary one. Treatment with 6MP accentuated the difference. It is discussed. whether the reduction of immunological memory in this experiment is due to cellular exhaustion or inhibition by the antibody produced.