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SYNERGISTIC EFFECT IN VIRAL‐BACTERIAL INFECTION
Author(s) -
Degré Miklos
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb00037.x
Subject(s) - leukocytosis , respiratory tract , virus , inoculation , biology , lung , respiratory system , bacteria , microbiology and biotechnology , virology , immunology , penicillin , antibiotics , medicine , genetics , anatomy
Polymorphonuclear (PMN) leukocyte accumulation in different sections of the respiratory tract of mice is a prominent sign after inoculation with parainfluenza 1 virus. Spontaneous invasion of bacteria to the lung, normally present in the upper respiratory tract, was frequently observed from the 2. day after viral inoculation. Penicillin‐G, administered in drinking water during the entire course of experiment eliminated the bacteria from the lungs. The extent of PMN leukocytosis was also reduced in the lungs and to a lesser extent in the circulating blood. The same treatment also reduced significantly the mortality which normally follows the virus infection. It is reasonable to believe that a bacterial invasion, secondary to the effect of primary virus inoculation, is responsible to some extent for the leukocyte accumulation in the respiratory organs, and it may participate in the infectious disease.