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AN EXPLANATION OF THE BIOLOGICAL ACTION OF TOXOTOXIN BASED ON SOME IN VITRO EXPERIMENTS
Author(s) -
Pettersen Eiliv K.
Publication year - 1971
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1971.tb00030.x
Subject(s) - fibrinolysis , in vitro , fibrin , in vivo , chemistry , thromboplastin , immunology , biology , medicine , coagulation , biochemistry , microbiology and biotechnology
The present investigation has failed to show any correlation between the lethal activity of Toxotoxin and the viscosity of its solutions. In vitro experiments in the presence of mouse plasma revealed a dual character of Toxotoxin, this being partly thromboplastin and partly coprecipitant to fibrin. In vivo , the thromboplastic activity, though in itself checked by fibrinolysis, was thought to initiate the coprecipitation of Toxotoxin, thus causing the formation of a massive clot which fibrinolysis would be unable to resolve.