Premium
THE EFFECT OF TRIMETHOPRIM ON ACUTE EXPERIMENTAL TOXOPLASMOSIS IN MICE
Author(s) -
Sander Jan,
Midtvedt Tore
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1970.tb04355.x
Subject(s) - trimethoprim , toxoplasma gondii , toxoplasmosis , sulfamethoxazole , sulfadiazine , significant difference , folic acid antagonists , microbiology and biotechnology , pyrimethamine , medicine , pharmacology , biology , antibiotics , immunology , folic acid , antibody , plasmodium falciparum , malaria
The effect of trimethoprim alone and in combination with sulphamethoxazole was investigated on mice experimentally infected with Toxoplasma gondii . The treatment was given per os. No effect was achieved with trimethoprim alone. Trimethoprim had, however, a significant sulphonamide potentiating effect on the survival‐time of mice intraperitoneally infected with T. gondii . The carrier rate after the treatments were concluded was higher among sulphonamide treated animals than among animals treated with both sulphonamide and trimethoprim, but the difference was not significant.