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IMMUNOFLUORESCENCE STUDIES ON KIDNEY BIOPSIES IN ANKYLOSING SPONDYLITIS
Author(s) -
LINDER E.,
PASTERNACK A.
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1970.tb04336.x
Subject(s) - ankylosing spondylitis , immunofluorescence , pathology , basement membrane , medicine , glomerular basement membrane , fibrinogen , kidney , spondylitis , staining , direct fluorescent antibody , antibody , immunology , glomerulonephritis
Six patients with ankylosing spondylitis were studied. Kidney biopsies were examined by light and fluorescent microscopy. Conventional staining revealed vascular changes, consisting of deposits in small arteries and arterioles, in three of the patients. Immunofluorescence revealed pathological changes in all six patients. Deposits of immunoglobulin, complement and fibrinogen in glomerular and tubular basement membranes as well as in the walls of small arteries and arterioles suggest that immunological processes are associated with ankylosing spondylitis.