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METABOLISM OF THALIDOMIDE IN PSEUDOMONAS AERUGINOSA NCTC A 7244
Author(s) -
MIDTVEDT TORE,
LINDSTEDT GÖRAN
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1970.tb04332.x
Subject(s) - phthalic acid , phthalimide , chemistry , pseudomonas aeruginosa , nitrogen , metabolism , ammonium , ammonium chloride , carbon source , thalidomide , phthalic anhydride , biochemistry , organic chemistry , biology , bacteria , genetics , catalysis , immunology , multiple myeloma
Thalidomide was found to support growth of Pseudomonas aeruginosa NCTC A 7244 when cultivated in a minimal medium containing thalidomide as sole source of carbon and nitrogen. Phthalic acid was found to be a metabolic end‐product. No evidence for hydroxy‐lation of phthalic acid was obtained. Glutarimide was utilized as sole source of carbon and nitrogen whereas 2‐(o‐carboxybenzoylamino) glutarimide, 2‐phthalimidoglutarate, and 2‐(o‐carboxybenzoylamino) glutarate did not support growth. Phthalimide could serve as source of nitrogen. Phthalate and its monohydroxyderivatives did not support growth with ammonium chloride present as nitrogen source.