Premium
FURTHER STUDIES ON M‐COMPONENTS WITH ANTISTREPTOLYSIN O ACTIVITY. THE INACTIVATING EFFECT ON DIFFERENT OXYGEN‐LABILE HAEMOLYSINS
Author(s) -
MANSA B.,
KJEMS E.
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1970.tb04329.x
Subject(s) - streptolysin , hemolysin , pneumolysin , microbiology and biotechnology , hemolysis , clostridium perfringens , neutralization , chemistry , toxin , toxoid , streptococcus pneumoniae , clostridium , biology , antibody , bacteria , immunology , biochemistry , antibiotics , immunization , bacterial protein , virulence , genetics , gene
Ten individual human serum samples with high concentrations of monoclonal γG globulins neutralizing streptolysin O were examined with three oxygen‐labile bacterial haemo‐lysins, which are antigenically related to streptolysin O. The haemolysins studied were pneumolysin of Diplococcus pneumoniae , tetanolysin of Clostridium tetani , and ø toxin of Glostridium perfringens (= Cl. welchii ). They were not inhibited to any appreciable extent by the human sera except in one of the thirty possible combinations. This exception was remarkable because the serum sample neutralized pneumolysin and streptolysin O equally well. The results are discussed in relation to the marked cross‐reactivity of immune sera from horses.