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THE EFFECT OF COMMERCIAL AND PURE GENTAMICIN ON THE GROWTH OF HUMAN DIPLOID LUNG FIBROBLASTS
Author(s) -
Litwin Jack
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1970.tb04302.x
Subject(s) - gentamicin , wi 38 , antibiotics , cell growth , ploidy , in vitro , chemistry , cell , lung , embryonic stem cell , bacterial growth , andrology , bacteria , biology , microbiology and biotechnology , biochemistry , medicine , genetics , gene
The effect of different concentrations of pure and commercial preparations of gentamicin on the growth of human embryonic diploid lung fibroblasts was studied. The commercial preparation was slightly more stimulatory than the pure antibiotic at concentrations of 1 μg/ml and 10 μg/ml. At concentrations of 100μg/ml and 500 μg/ml the commercial preparation was toxic but the pure antibiotic still permitted growth. Cell growth was stimulated above that of the control and cell longevity in vitro increased with 10 μg/ml. Gentamicin had no effect on cell adsorption at any of the concentrations used.