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OPSONIZING AND BACTERICIDAL EFFECTS OF SERA FROM GNOTOBIOTIC AND CONVENTIONALIZED RATS ON 32 P‐LABELLED E. COLI.
Author(s) -
Midtvedt Tore,
Trippestad Arne
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section b microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5563
DOI - 10.1111/j.1699-0463.1970.tb04264.x
Subject(s) - microbiology and biotechnology , escherichia coli , in vitro , biology , strain (injury) , chemistry , biochemistry , gene , anatomy
Using an in vitro system based upon radioisotope technique, the opsonizing and bactericidal effects upon E. coli of sera from germfree, E. coli and B. subtilis monocontaminated, and conventionalized rats, were investigated. Sera from the germfree animals were found to possess opsonizing as well as bacteriotoxic properties. The opsonizing activity was highest in sera from rats monocontaminated with E. coli , and lowest in sera from germfree animals. The bactericidal activity was lowest in sera from germfree rats. Specific and unspecific monocontaminations as well as conventionalization increased the serum bactericidal activity against the strain of E. coli used.