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THE EFFECT OF HEAT‐LABILE SERUM FACTORS ON VITAMIN D‐INDUCED ARTERIOSCLEROSIS IN MICE
Author(s) -
Geertinger P.,
Strannegård Ö.,
Sørensen H.
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb03525.x
Subject(s) - arteriosclerosis , medicine , endocrinology , guinea pig , vitamin , complement (music) , blood serum , chemistry , biochemistry , complementation , gene , phenotype
Administration of fresh guinea pig serum to vitamin D‐treated mice greatly promoted the induction of arteriosclerotic vascular changes. Heat inactivated guinea pig serum had no such effect. Since mice have minimal serum complement concentrations the results suggest a role of complement in vitamin D‐induced arteriosclerosis. This hypothesis would be compatible with the earlier finding that decomplementation of rats prevents the development of vitamin D‐induced arteriosclerosis in these animals.