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ULTRASTRUCTURE OF GRANULAR CELL MYOBLASTOMA
Author(s) -
Henrik Per,
Carstens Becher
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb03521.x
Subject(s) - ultrastructure , homogeneous , electron microscope , neurofilament , anatomy , histiocyte , basement membrane , granular cell , intermediate filament , cytoplasm , chemistry , cell , biophysics , pathology , biology , microbiology and biotechnology , cytoskeleton , physics , immunohistochemistry , central nervous system , medicine , neuroscience , biochemistry , optics , thermodynamics
Granular cell myoblastomas are among the controversial tumors. Not only has there been disagreement about their origin but also about whether the entity represents a neoplasm or a histiocytic response. In this electron microscopic study of three granular cell myoblastomas, support for the neurogenic origin was obtained by the finding of tumor cells with distinct basement membranes, containing cell inclusions of three different kinds and varying amounts of unmyelinated axons. The three cell inclusions were: The osmiophilic concentric lamellae; the homogeneous lighter bodies, and the aggregates of tubular filaments. The study demonstrated that the osmiophilic concentric lamellae and the homogeneous lighter bodies take origin from degenerating mitochondria within the unmyelinated axons and the aggregates of tubular filaments appear to take origin from the neurofilament within the unmyelinated axons.