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SPECIES SPECIFIC DIFFERENCES IN CONVERTING ENZYME AND IN ANGIOTENSIN I
Author(s) -
Poulsen Knud,
Bing Jens
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb03518.x
Subject(s) - renin–angiotensin system , in vitro , in vivo , enzyme , angiotensin ii , angiotensin converting enzyme , medicine , endocrinology , biology , plasma renin activity , chemistry , biochemistry , blood pressure , genetics
The renin‐system of mice, which has previously been shown to have a unique specificity of angiotensinogen, is shown also to differ from that of rat and man as regards its plasma converting enzyme and its angiotensin I. While these species differences are marked in in vitro studies, they cannot be shown by intravenous injection of mouse angiotensin I into rats. The differences between in vitro and in vivo experiments can be due to qualitative or quantitative differences between plasma and lung converting enzyme. There was so far no demonstrable difference between mouse, rat and human angiotensin II, as they reacted in a similar way with antiangiotensin II.