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THE EFFECT OF REPEATED INJECTIONS OF RABBIT ANTI‐GUINEA‐PIG THYROGLOBULIN SERUM INTO GUINEA‐PIGS
Author(s) -
Kåresen Rolf
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb03516.x
Subject(s) - thyroglobulin , guinea pig , antibody , endocrinology , medicine , chemistry , globulin , basal (medicine) , biology , thyroid , immunology , insulin
By repeated intraperitoneal injections of rabbit anti‐guinea‐pig thyroglobulin serum into guinea‐pigs, a high level of precipitating antibody to thyroglobulin was obtained in their serum for periods as long as 40 days. Although rabbit γ‐globulin, most probably anti‐thyroglobulin antibodies, was found as large deposits intercellularly and between the basal plasma membrane and the basement membrane of the follicle cells, no intracellular changes could be observed. No accumulation of mononuclear cells was detected in the interstitium, and in contrast to the heavy infiltration of granulocytes observed 24 hours after a single injection, only scattered eosinophils were found after repeated injections.