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THE POSSIBLE CARCINOGENIC PROPERTIES OF ALTERED LIPIDS
Author(s) -
Glavind J.,
Arffmann E.
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb03310.x
Subject(s) - isomerization , chemistry , linoleic acid , oleic acid , carcinogen , context (archaeology) , double bond , serial dilution , bioassay , methyl oleate , organic chemistry , biochemistry , stereochemistry , fatty acid , biology , catalysis , ecology , medicine , paleontology , pathology , alternative medicine
Methyl oleate, methyl linoleate and a number of derivatives of the two esters, all highly purified, were examined by the newt test. The substances were tested in serial dilutions in order to establish dose‐response relationships. The most active compound was methyl 12‐oxo‐ trans ‐10‐octadecenoate. The esters of oleate and linoleate hydroperoxide and the corresponding hydroxy‐compounds, obtained by reduction of the hydroperoxides, were also active. Conjugation of the double bonds in linoleic acid gave a weak activity, and the compounds obtained by trans ‐isomerization of the double bonds in oleic and linoleic acid were estimated as inactive. The results are discussed in context with previous results. In the evaluation of the newt test as a rapid bioassay for carcinogenicity, inconveniences due to seasonal variations in susceptibility are stressed.