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INTERACTION BETWEEN OESTROGENIC AND CARCINOGENIC SUBSTANCES IN THE RAT MAMMARY GLAND
Author(s) -
Sander Sten,
Torgersen Olav
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb03304.x
Subject(s) - dmba , mammary gland , carcinogen , hormone , medicine , endocrinology , breast cancer , cancer , biology , carcinogenesis , biochemistry
The cyclic variations in the rat mammary gland seem to be of no significance for the induction of breast cancer by dimethylbenzanthracene (DMBA) nor for the development of hormone sensitivity in these tumours. The uptake studies give no indication of any competition between oestradiol and DMBA with regard to intracellular binding. The occasional occurrence of one hormone‐sensitive and one hormone‐resistant cancer in the same animal points to the significance of local factors for the development of hormone‐sensitivity in breast cancers.