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COMPLEMENT AS A FACTOR IN ARTERIOSCLEROSIS
Author(s) -
Geertinger Preben,
Sørensen Henning
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb03303.x
Subject(s) - arteriosclerosis , medicine , complement (music) , aorta , vitamin , vitamin d and neurology , cardiology , biology , biochemistry , complementation , gene , phenotype
Massive doses of vitamin‐D in a few days provoke heavy clinical symptoms and histologically significant vascular changes, particularly in the aorta, coronary arteries and renal vessels of rats. Intravenous administration of zymosan completely cuts out these effects. Our conclusion is, therefore, that inactivation of circulating complement inhibits the vitamin‐D produced arterial lesions. We suggest that complement not only is an important factor in arteriosclerosis produced by vitamin‐D poisoning, but find it conceivable that it may play a similar key role in human aortic and coronary sclerosis.