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HISTOLOGICAL CHANGES IN LIVER BIOPSIES FROM PATIENTS WITH SURGICAL BILE DUCT DISORDERS
Author(s) -
Poulsen Hemming,
Christoffersen Per
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb02542.x
Subject(s) - cholestasis , bile duct , medicine , biliary tract , gastroenterology , common bile duct , infiltration (hvac) , left hepatic duct , fibrous capsule of glisson , pathology , physics , thermodynamics
The degree and incidence of a long series of histologic qualities from a total of 113 surgical biopsies from patients with surgical disorders of the biliary tract have been registered and correlated. The material has been divided into four groups, where both group I and II are from patients with operatively and radiologically verified obstruction (respectively with and without cholestasis), and group III and IV from patients without obstruction (likewise respectively with and without cholestasis). Two findings are of special interest. The first is, that the two groups with obstruction of the common bile duct, of which group II must be considered to have less pronounced obstruction than group I, with significantly greater frequency exhibit marginal bile duct proliferation than the groups without obstruction. The second is, that the group with obstruction and cholestasis (group I) with significantly greater frequency exhibits portal oedema and infiltration with granulocytes than the other three groups. We have interpreted the first finding as a manifestion of the bile ducts in the marginal zones of the portal areas being the sectors of the biliary tract which with greatest ease react to an increase in pressure. The second finding indicates—in connection with the fact that infiltration with neutrophil granulocytes and oedema are found most pronounced in the vicinity of proliferating marginal bile ducts with more or less disentegrated epithelium—that the acute portal inflammation in extrahepatic obstruction is secondary to more severe marginal bile duct proliferation.