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ALTERATION OF KARYOTYPIC PROFILES IN HUMAN CANCEROUS EFFUSION FOLLOWING TREATMENT WITH ANTINEOPLASTIC DRUG
Author(s) -
Visfeldt Jakob,
Lundwall Finn
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb02539.x
Subject(s) - chromosome , cancer , drug , chemotherapy , biology , selection (genetic algorithm) , cancer research , effusion , medicine , pathology , genetics , pharmacology , surgery , gene , computer science , artificial intelligence
It is a characteristic feature of human cancerous effusions that the cells show great variation and, in particular, it is generally emphasized that therapy does not exert any influence on the chromosomal constitution of the cancer cells. Selection of a cell line during treatment is stated to occur very infrequently. Such a selection of a cell line with a constant number of chromosomes was demonstrated by repeated chromosome analyses in a patient during chemotherapy. The results of the studies are described, and the practical and theoretical aspects are commented upon. – Alterations in the karyotypic profiles in cancerous effusions during treatment with chemotherapeutic agents will require consideration of changing to another agent.