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TUBULAR AND INTERSTITIAL NEPHRITIS PRODUCED BY HOMOLOGOUS HEART HOMOGENATE IN RABBITS
Author(s) -
Wegelius Otto,
Jokinen E. J.
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb02516.x
Subject(s) - interstitial nephritis , homologous chromosome , nephritis , urine , myoglobin , intraperitoneal injection , subcutaneous injection , pathology , infiltration (hvac) , creatinine , myofibril , kidney , medicine , nephron , chemistry , endocrinology , biochemistry , materials science , composite material , gene
Repeated intraperitoneal and subcutaneous injections of undenatured homologous myocardial homogenates into rabbits results in an irreversible kidney disease in the majority of the animals. The lesion starts about eighteen weeks after the start of the experiment in the cells of the proximal convoluted tubules and around these structures as an interstitial infiltration of mononuclear cells. At forty weeks kidney impairment is obvious, as shown by elevated serum creatinine, changes in serum protein level and electrophoretic pattern, electrolyte disturbances and protein in the urine. The kidneys are partly shrunken, resembling “peach stones”. Myoglobin and/or some other component in the homologous homogenate is thought to be the agent responsible. The findings are interpreted as an experimental model of chronic tubular and interstitial nephritis in man.