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GUINEA PIGS AND CARCINOGENS
Author(s) -
Stenbäck Frej
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb00253.x
Subject(s) - carcinogen , guinea pig , dose , carcinogenesis , skin tumours , medicine , transplantation , pathology , physiology , biology , cancer , genetics
The reaction of guinea pig skin to topical and subcutaneous administration of four carcinogens administered in different dosages to newborn and adult animals, has been investigated histologically and histochemically. The transplantability of the sarcomas produced, and the occurrence of spontaneous tumours in the strain used, was studied too. The guinea pig was resistant to topical carcinogen treatment, but large doses administered during a long period did induce tumorigenesis. The resulting tumours were all fibrosarcomas. The newborn animals were as resistant as adults. The transplantation of the tumours was successfull, but the percentage of positive “takes” was small. A single dermal tumour occurred spontaneously in the control group consisting of 500 animals.