Premium
HISTOCHEMICAL LOCALIZATION OF VARIOUS ENZYMES IN HUMAN FATTY LIVER CAUSED BY MODERATE ALCOHOL CONSUMPTION
Author(s) -
Petersen Palle
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb00250.x
Subject(s) - acid phosphatase , alkaline phosphatase , enzyme , biochemistry , atpase , fatty acid , phosphatase , fatty liver , esterase , oxidative phosphorylation , chemistry , biology , medicine , disease
Histochemical examinations including demonstration of acid phosphatase, alkaline phosphatase, ATPase, non‐specific esterase and various oxydative enzymes were performed on biopsy specimens from patients with fatty liver caused by moderate alcohol consumption. In the fatty livers degeneration changes was found by demonstrating lysosomal changes by acid phosphatase reaction. By means of non‐specific esterase and oxydative enzyme reactions both degenerating and regenerating cells were found. Lack of enzyme activity in cells and morphological changes in the reaction product of NADH‐diaphorase indicated mitochondrial damage. ATPase and alkaline phosphatase demonstrated the sinusoids and biliary capillaries. Displacement of the biliary capillaries was found in some of the livers presenting fatty degeneration.