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TUMOUR GROWTH AND SPONTANEOUS METASTASIS SPREAD IN TWO SYNGENEIC SYSTEMS
Author(s) -
Hagmar Björn
Publication year - 1970
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1970.tb00248.x
Subject(s) - metastasis , heparin , melanoma , medicine , fibrin , thrombosis , phenprocoumon , cancer research , pathology , oncology , cancer , immunology , warfarin , atrial fibrillation
In two syngeneic tumour‐host systems, MCGl‐AS in CBA mice and melanoma B16 in C57BL/6J mice, the time of onset of spontaneous metastasis spread was determined, so was how removal of the primary tumours affected the amount of metastases. Treatment with two anticoagulants (heparin and phenprocoumon) and an antifibrinolytic (EACA) was instituted for 6 days, when metastatic spread was beginning. Heparin increased metastasis formation from MCGl‐AS and a similar trend was found in the case of melanoma B16. The coumarin anticoagulant, phenprocoumon, had no such effect. None of the substances seemed to affect the growth of MCGl‐AS metastases, when the treatment was instituted after resection of the primary tumours. This was the case also of EACA, but this substance tended to reduce tumour weights and metastasis formation in both systems, if applied before removal of tumours. The results seem to offer evidence against the concept that thrombosis around disseminated tumour cells promotes the development of metastases. The location of fibrin in subcutaneously transplanted tumours was also studied in histological sections.