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SEX DIFFERENCES IN THE INTRAPERITONEAL GROWTH OF EHRLICH'S ASCITES CARCINOMA
Author(s) -
Hartveit F.
Publication year - 1963
Publication title -
acta pathologica microbiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5555
DOI - 10.1111/j.1699-0463.1963.tb04825.x
Subject(s) - ehrlich ascites carcinoma , ascites , carcinoma , rest (music) , biology , pathology , neoplasm , medicine , tumor cells , cancer research
The morphological changes in Ehrlich ascites carcinoma cells were followed by serial biopsy. The number of large injured cells was found to increase with time until a critical percentage (30 per cent) was reached. Thereafter there were a few large injured tumour cells while the rest were pyknotic. Large injured tumour cells reappeared in later biopsies but were of different morphology from those preceding pyknosis. It seems likely that the injury in the latter cells is due to immunological damage while that in the former may well be the result of anoxia. There was a marked sex difference in the mode of growth of the tumour in that pyknosis occurred earlier in the females. This supports the author's previous findings ( Hartveit 1962a and 1963a) that female mice have greater natural immunity to Ehrlich's ascites carcinoma than males.