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TREATMENT OF POST‐IRRADIATION INFECTIONS IN MICE
Author(s) -
Laurell G.,
Philipson L.
Publication year - 1956
Publication title -
acta pathologica microbiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-5555
DOI - 10.1111/j.1699-0463.1956.tb03161.x
Subject(s) - streptomycin , gamma irradiation , irradiation , strain (injury) , mononuclear phagocyte system , pharmacology , microbiology and biotechnology , biology , immunology , chemistry , medicine , antibiotics , physics , nuclear physics
SUMMARY White mice of a homologous strain were exposed to total‐body x‐irradiation, the dose ranging from 600 to 750 r. They were treated for varying periods with streptomycin alone, RES—(reticuloendothelial system)—stimulating substances, or a combination of these two media. All the substances were administered with the micro‐injection technique. Streptomycin alone in a dose of 1000 gamma per animal per day is found to have some effect against bacterial infections. RES‐stimulating substances alone or in combination with streptomycin do not give uniform results. The experimental conditions in this type of experiment are discussed.