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Unexpected extra‐renal effects of loop diuretics in the preterm neonate
Author(s) -
Cotton Robert,
Suarez Sandra,
Reese Jeff
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2012.02699.x
Subject(s) - bumetanide , medicine , furosemide , diuretic , loop diuretic , ductus arteriosus , pharmacology , endocrinology , cotransporter , sodium , chemistry , organic chemistry
The loop diuretics furosemide and bumetanide are commonly used in neonatal intensive care units (NICUs). Furosemide, because of its actions on the ubiquitous Na + –K + –2Cl − isoform cotransporter and its promotion of prostanoid production and release, also has non‐diuretic effects on vascular smooth muscle, airways, the ductus arteriosus and theoretically the gastrointestinal tract. Loop diuretics also affect the central nervous system through modulation of the GABA‐A chloride channel. Conclusion: The loop diuretics have a variety of biological effects that are potentially harmful as well as beneficial. Care should be taken with the use of these agents because the range of their effects may be broader than the single action sought by the prescribing physician.