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Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia
Author(s) -
Rogers Lynette K,
Young Christine M,
Pennell Michael L,
Tipple Trent E,
Leonhart Karen L,
Welty Stephen E
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2012.02694.x
Subject(s) - bronchopulmonary dysplasia , medicine , gestational age , confounding , gestation , lipid metabolism , metabolite , physiology , pathogenesis , small for gestational age , endocrinology , pregnancy , biology , genetics
Aim: To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age. Methods: Infants born <32 weeks’ gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC‐MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis. Results: Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age. Conclusion: Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.