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Precursors of adrenomedullin, endothelin and atrial natriuretic peptide as diagnostic markers of neonatal infection
Author(s) -
Cao Yun,
Xia Qing,
Chen Chao,
Yang Yi
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2011.02511.x
Subject(s) - medicine , adrenomedullin , natriuretic peptide , atrial natriuretic peptide , biomarker , endothelin 1 , endothelin receptor , receiver operating characteristic , gastroenterology , diagnostic biomarker , area under the curve , endocrinology , diagnostic accuracy , receptor , heart failure , chemistry , biochemistry
Aim: To evaluate the serum levels of three precursors of vasoactive peptide as diagnostic markers for neonatal infections. Methods: Overall, 356 neonates (160 without infection, 114 with mild infections and 82 with severe infections) were enrolled in this study. Their serum levels of mid‐regional pro‐adrenomedullin (MR‐pro‐ADM), C‐terminal pro‐endothelin‐1 (CT‐pro‐ET‐1) and mid‐regional pro‐atrial natriuretic peptide (MR‐pro‐ANP) were measured by immunoassay, and receiver operating curve analysis was performed for each biomarker to evaluate their diagnostic values for neonatal infection. Results: The serum levels of MR‐pro‐ADM (2.079 ± 1.195 n m ), CT‐pro‐ET‐1 (109.4 ± 62.9 p m ) and MR‐pro‐ANP (1221.4 ± 725.0 p m ) in the severe infection group were significantly higher than those in the mild infection group (1.025 ± 0.421 n m , 86.7 ± 51.8 p m , and 687.6 ± 575.7 p m , respectively) and in the non‐infection group (0.853 ± 0.488 n m , 51.3 ± 40.6 p m , and 943.3 ± 847.3 p m , respectively) (p < 0.01–0.001). Their areas under the curve were 0.72, 0.76 and 0.61, respectively. Among them, CT‐pro‐ET‐1 had the highest sensitivity (82.65%), whereas MR‐pro‐ADM had the highest specificity (86.25%). Conclusions: MR‐pro‐ADM, CT‐pro‐ET‐1 and MR‐pro‐ANP may serve as useful laboratory markers to indicate bacterial infection in neonates.