Premium
Development of smooth pursuit eye movements in very preterm born infants: 3. Association with perinatal risk factors
Author(s) -
Strand Brodd Katarina,
Grönqvist Helena,
Holmström Gerd,
Grönqvist Erik,
Rosander Kerstin,
Ewald Uwe
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2011.02449.x
Subject(s) - medicine , retinopathy of prematurity , periventricular leukomalacia , bronchopulmonary dysplasia , gestational age , risk factor , pediatrics , univariate analysis , intraventricular hemorrhage , population , ductus arteriosus , pregnancy , multivariate analysis , genetics , environmental health , biology
Aim: To investigate the association between perinatal risk factors and neonatal complications and early oculo‐motor development in very preterm infants. Methods: Perinatal risk factors were identified, and the potential association with early oculo‐motor development was evaluated by measuring smooth pursuit eye movements (SP) at 2 and 4 months’ corrected age (CA) in a population of very preterm infants born in Uppsala County 2004–2007 (n = 113). Results: Among the 15 tested factors, eight showed significant association in univariate analysis with lower levels of SP at 4 months’ CA, namely administration of prenatal corticosteroids, gestational age, birthweight, bronchopulmonary dysplasia, retinopathy of prematurity, periventricular leukomalacia, intraventricular haemorrhage >grade 2, and persistent ductus arteriosus. At 2 months’ CA, only retinopathy of prematurity >stage 2 was associated with lower levels of SP. When all factors significant in the univariate tests were included in multiple regressions aimed to assess each factor’s independent relation to SP, periventricular leukomalacia was the only significant independent factor. When adding 2–5 of the significant factors using multiple regression analysis, the levels of SP became lower. Conclusion: Perinatal risk factors were associated with lower levels of SP. This could be interpreted as delayed or disturbed development of normal oculomotor ability.