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Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity
Author(s) -
Wikstrand Margareta Hök,
Hård AnnaLena,
Niklasson Aimon,
Smith Lois,
Löfqvist Chatarina,
Hellström Ann
Publication year - 2011
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2011.02394.x
Subject(s) - medicine , retinopathy of prematurity , birth weight , gestational age , prospective cohort study , white blood cell , pediatrics , gestation , low birth weight , logistic regression , obstetrics , physiology , pregnancy , genetics , biology
Aim: To identify factors associated with poor early weight gain as reflected in an alarm system, WINROP, and risk of later proliferative retinopathy of prematurity (ROP) in infants with gestational age (GA) < 28 weeks. Methods: Infants with a WINROP alarm and proliferative ROP, the ‘alarm group’ (n = 23), were matched to GA and gender to a ‘no alarm group’ (n = 23) with no WINROP alarm and no or mild ROP. Retrospectively maternal variables, birth characteristics and neonatal factors, during the first three postnatal weeks, were compared. Results: The ‘alarm group’ had lower birth weight (BW) and BW standard deviation score, longer stay in ventilator, more insulin and corticosteroid treatments, and lower white blood cell count. In a logistic regression model, BW standard deviation score, insulin, low white blood cell count, absence of both elevated C‐reactive protein and premature rupture of membranes were associated with proliferative ROP and WINROP alarm (p = 0.000, r 2 = 0.704). Conclusions: This study shows that prenatal factors resulting in low BW have persisting effects on early postnatal growth, metabolism and inflammatory response. Future prospective studies will focus on the link between these factors and pathological retinal vessel development in the early postnatal period to find possible preventive strategies.