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Inappropriate antidiuretic hormone secretion: long‐term successful urea treatment
Author(s) -
Chehade Hassib,
Rosato Luigi,
Girardin Eric,
Cachat Francois
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2011.02382.x
Subject(s) - hyponatremia , medicine , antidiuretic , urea , intensive care medicine , hormone , complication , fluid restriction , syndrome of inappropriate antidiuretic hormone secretion , pediatrics , endocrinology , chemistry , organic chemistry
Hyponatremia is the main complication of inappropriate antidiuretic hormone secretion (SIADH), sometimes fatal. Treatment strategy depends on the cause and the severity of the hyponatremia. Recent studies have shown the efficacy of urea in treating acute hyponatremia secondary to SIADH, by inducing an osmotic water drive. We describe an infant with chronic hyponatremia secondary to SIADH in which the long‐term oral treatment with urea was successful and well tolerated. The aim of this paper is to highlight the potential benefits of urea treatment in case of chronic hyponatremia secondary to SIADH. Conclusion: Chronic oral urea treatment in children with SIADH allows an easy and safe water and sodium control and may permit a decrease in fluid restriction in this situation.