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Associations between vitamin D status in infants and blood lipids, body mass index and waist circumference
Author(s) -
Arnberg K,
Østergård M,
Madsen AL,
Krarup H,
Michaelsen KF,
Mølgaard C
Publication year - 2011
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2011.02273.x
Subject(s) - medicine , body mass index , waist , vitamin d and neurology , endocrinology , breastfeeding , pediatrics
Aim: To study the relationships between 25‐hydroxyvitamin D status and blood lipids, insulin, glucose, body mass index and waist circumference in infants. Methods: In a cross‐sectional study, 255 infants aged 9 months with a blood sample for 25‐hydroxyvitamin D were examined. Plasma 25‐hydroxyvitamin D concentrations were analysed by chemiluminescent immunoassay. Associations between plasma 25‐hydroxyvitamin D and high‐density lipoprotein (HDL), low‐density lipoprotein, total cholesterol, triglycerides, insulin, glucose, body mass index and waist circumference were analysed. Results: Mean plasma 25‐hydroxyvitamin D was 77.2 ± 22.7 nM. At the time of examination, 97% received vitamin D supplementation. 25‐Hydroxyvitamin D was negatively associated with HDL (p = 0.003), cholesterol (p = 0.002) and triglycerides (p = 0.010) in multivariate analysis controlled for gender, season, body mass index, length, birth weight and breastfeeding. There were no associations between 25‐hydroxyvitamin D and glucose or insulin (all p > 0.05). 25‐hydroxyvitamin D was negatively associated with body mass index (p = 0.005) and waist circumference (p = 0.002) controlled for gender, season, breastfeeding, birth weight and length. Conclusion: Vitamin D status is negatively associated with blood lipids, body mass index and waist circumference in infants where nearly all received vitamin D supplements. Whether this has long‐term health effects remains to be elucidated.