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Severe immune haemolytic anaemia due to ceftriaxone in a patient with congenital nephrotic syndrome
Author(s) -
Reis Boto Maria Leonor,
Sandes Ana Rita,
Brites Anabela,
Silva Susana,
Stone Rosário,
Almeida Margarida
Publication year - 2011
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2011.02268.x
Subject(s) - medicine , ceftriaxone , haemolysis , antibiotics , sepsis , shock (circulatory) , nephrotic syndrome , immune system , immunology , surgery , microbiology and biotechnology , biology
Aim: To describe the first case of ceftriaxone‐related haemolysis in a patient with congenital nephrotic syndrome (CNS). Background: Severe haemolysis caused by an immune reaction to ceftriaxone has mostly been described in patients with underlying haematological or immune dysfunction. Case report: The authors present a 20‐month‐old boy with CNS of the Finnish type with several previous severe infections treated with ceftriaxone, admitted for suspected sepsis. Following ceftriaxone administration he developed shock secondary to an acute haemolytic reaction, with severe anaemia. Hypersensitivity to ceftriaxone was documented through positive agglutination tests. Conclusion: Onset of haemolysis following ceftriaxone administration, particularly in a patient previously exposed to the drug, must raise the suspicion of a possible immune reaction.