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Clinical accuracy of anti‐tissue transglutaminase as screening test for celiac disease under 2 years
Author(s) -
Panetta Fabio,
Torre Giuliano,
Colistro Franco,
Ferretti Francesca,
Daniele Antonella,
Diamanti Antonella
Publication year - 2011
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2010.02124.x
Subject(s) - medicine , tissue transglutaminase , gastroenterology , hepatology , biopsy , pediatric gastroenterology , histology , villous atrophy , disease , coeliac disease , chemistry , biochemistry , enzyme
Aim: To investigate, in patients with suspected celiac disease (CD) younger than 2 years, the clinical value of anti‐tissue transglutaminase (tTG) in diagnostic work‐up of CD. Methods: Between June 2005 and June 2009, 169 patients aged <2 years, with symptoms suggestive of CD, were submitted to biopsy. CD diagnosis was based on the revised criteria of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. Results: Of the 169 patients enrolled, 155 were included: 108 of them showed mucosal atrophy and 47 negative histology. Sensitivity and specificity of tTG, at the cut‐off of 8 AU/mL, were 0.96 (CI 0.91–0.99) and 0.91 (CI 0.80–0.98), respectively, with likelihood ratio (LR) of 11.31; at the cut‐off of 16 AU/mL, they were 0.79 (CI 0.70–0.86) and 1.00, respectively (CI 0.92–1.00), with LR 4.50. Conclusions: In patients younger than 2 years, suspected for CD, tTG is very valuable in selecting for small intestinal biopsy.