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Plasma long‐chain fatty acids profile and metabolic outcomes in normolipidaemic obese children after one‐year nutritional intervention
Author(s) -
Verduci Elvira,
Radaelli Giovanni,
Salvioni Michela,
Riva Enrica,
Giovannini Marcello
Publication year - 2011
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2010.02120.x
Subject(s) - medicine , insulin resistance , polyunsaturated fatty acid , body mass index , confidence interval , homeostatic model assessment , endocrinology , obesity , insulin , fatty acid , biochemistry , chemistry
Aim: To assess the association between changes in plasma long‐chain polyunsaturated fatty acids (LCPUFAs) profile and metabolic outcomes after 1‐year nutritional intervention in normolipidaemic obese children. Methods: Fifty‐seven normolipidaemic obese children, aged 8–13 years, were recruited in the study. Body mass index (BMI) z‐scores were calculated. Fasting blood samples were analysed for insulin, glucose, lipid profile and fatty acid (FA) levels at baseline and after an 1‐year nutritional‐behaviour intervention. Insulin resistance was estimated by homeostatic model assessment (HOMA). Results: Fifty‐one obese children completed the study. At the end of the intervention, the children showed decreased BMI z‐score (mean reduction 0.25; 95% confidence interval [CI], 0.18–0.31), HOMA index (1.6; 0.6–2.5), plasma‐saturated FA (1.49; 0.67–2.31 mg/dL), C20:3n‐9 (0.05; 0.02–0.07 mg/dL) and increased plasma levels of monounsaturated FA (mean increase 1.35; 0.63–2.07 mg/dL), n‐6 PUFA (1.02; 0.08–1.97 mg/dL), n‐3 PUFA (0.24; 0.07–0.40 mg/dL), C20:4n‐6 (0.37; 0.11–0.63 mg/dL), C18:3n‐3 (0.04; 0.01–0.07 mg/dL), C22:6n‐3 (0.30; 0.17–0.42 mg/dL) and the C22:6n‐3/C20:4n‐6 ratio (0.02; 0.01–0.03 mg/dL) ratio. Conclusions: Nutritional interventions may improve plasma LCPUFA profile and metabolic outcomes of normolipidaemic obese children.