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Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis in Denmark 1994–2006: A nationwide population‐based study
Author(s) -
Tuckuviene R,
Christensen AL,
Helgestad J,
Johnsen SP,
Kristensen SR
Publication year - 2011
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2010.02100.x
Subject(s) - medicine , incidence (geometry) , pediatrics , population , case fatality rate , stroke (engine) , thrombosis , surgery , mechanical engineering , physics , environmental health , optics , engineering
Aim: To assess the incidence rates (IR), clinical characteristics, risk factors, treatment and outcomes of paediatric arterial ischaemic stroke (AIS) and cerebral sinovenous thrombosis (CSVT). Methods: Using population‐based, nationwide medical registries, we identified all patients aged 0–18 years at the time of hospitalization with first‐ever AIS and/or CSVT in Denmark between 1994 and 2006. Medical records were retrieved and reviewed. Results: We identified 211 patients with AIS and 40 patients with CSVT corresponding to IRs of 1.33 (95% CI 1.16–1.52) and 0.25 (95% CI 0.19–0.34) per 100 000 person‐years, respectively. The IRs peaked in infancy (<1 year) for both AIS and CSVT with an additional peak among adolescents (15–18 years) for CSVT. The IR of AIS increased 3.9% per year (p = 0.036), whereas no changes were found for CSVT. In total, 48.2% of the patients received antithrombotic treatment; no major complications were observed. All‐cause and thrombosis‐related 30‐day case fatality ratios were 3.6% and 2.4%, respectively; neurological sequelae were found in 56.2% of patients. Conclusion: The IR of AIS was highest in infants and had increased with 3.9% annually during the observation period. The IR of CSVT had an additional peak in adolescence and remained unchanged over time.