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X‐linked agammaglobulinemia complicated with endobronchial tuberculosis
Author(s) -
Kawakami Chihiro,
Inoue Akiko,
Takitani Kimitaka,
Kanegane Hirokazu,
Miyawaki Toshio,
Tamai Hiroshi
Publication year - 2011
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2010.02071.x
Subject(s) - medicine , tuberculosis , quantiferon , immunology , mycobacterium tuberculosis , pathology , latent tuberculosis
Aim: We report a case of X‐linked agammaglobulinemia complicated with endobronchial tuberculosis. Methods: We observed the patient’s clinical course and analysed his data retrospectively. Results: Interestingly, the T‐cell proliferation activity in this patient was intact, and the CD4‐positive T cells produced interferon gamma. However, the result of the quantiferon alpha‐2b test was negative. Conclusion: The findings of this case suggest that the quantiferon alpha‐2b test may not be diagnostic for tuberculosis not only in patients with T‐cell disorders but also in cases with B‐cell deficiencies such as X‐linked agammaglobulinemia.