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Smoking in pregnancy: a risk factor for adverse neurodevelopmental outcome in preterm infants?
Author(s) -
KiechlKohlendorfer U,
Ralser E,
Pupp Peglow U,
Reiter G,
Griesmaier E,
Trawöger R
Publication year - 2010
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2010.01749.x
Subject(s) - medicine , pregnancy , pediatrics , bayley scales of infant development , psychomotor learning , gestational age , retinopathy of prematurity , gestation , low birth weight , small for gestational age , birth weight , obstetrics , risk factor , psychiatry , genetics , cognition , biology
Aim: To assess whether smoking in pregnancy influences neurodevelopmental outcome at 2‐years of age in preterm infants with a gestational age <32 weeks. Methods: Between January 2003 and December 2005 we prospectively enrolled 181 infants born alive between 23 and 32 weeks of gestation; 142 infants (78.5%) completed the follow‐up visit. The association between candidate risk factors and delayed motor or mental development (Bayley Scales of Infant Development II; psychomotor or mental developmental index <85) was analysed by means of logistic regression analysis. Results: Low maternal age, smoking in pregnancy, low gestational age, low birth weight, small for gestational age, chronic lung disease, intracerebral haemorrhage, periventricular leucomalacia, and retinopathy of prematurity (stages 3 and 4) all were associated with an increased risk for delayed development (p < 0.05, each). Smoking in pregnancy, small for gestational age and chronic lung disease maintained significance in a multivariable analysis. Conclusion: Smoking in pregnancy emerged as a risk predictor for adverse neurodevelopmental outcome in our study. Strategies to reduce smoking in pregnancy should be further endorsed.