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The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment
Author(s) -
Hallberg B,
Grossmann K,
Bartocci M,
Blennow M
Publication year - 2010
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2009.01653.x
Subject(s) - medicine , hypothermia , encephalopathy , pediatrics , electroencephalography , neonatal encephalopathy , cohort , anesthesia , full term , pregnancy , psychiatry , biology , genetics
Background: Induced moderate hypothermia (HT) for 72 h has been shown to reduce the combined outcome of death or severe neurodevelopmental disabilities in asphyxiated full‐term infants. A pathological amplitude integrated EEG background as early as 3–6 h after birth, has been shown to correlate to poor prognosis. Aim: The aim of this study was to investigate the correlation between amplitude integrated EEG during HT treatment and short‐term outcome in asphyxiated full‐term infants with moderate/severe hypoxic‐ischaemic encephalopathy. Methods: Between December 2006 and December 2007, 24 infants were treated with moderate HT (33.5°C for 72 h) using a cooling mattress. Motor functions were assessed at 4 and 12 months of age. Results: Of the total birth cohort of 28,837 infants, 26 infants fulfilled the criteria for HT treatment (0.9/1000) of whom 23 was treated with HT and all of these infants had available amplitude integrated EEG data. Normal 1‐year outcome was found in 10/15 infants with severely abnormal burst‐suppression pattern or worse at 6 h of age. Severe abnormalities were found to be significantly predictive for abnormal outcome after 36 h. Conclusion: Among asphyxiated infants treated with HT, only those who had aEEG abnormalities persisting at and beyond 24 h after birth showed poor neurological outcome at 1 year.