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Meta‐analysis of blood pressure tracking from childhood to adulthood and implications for the design of intervention trials
Author(s) -
Toschke AM,
Kohl L,
Mansmann U,
Von Kries R
Publication year - 2010
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2009.01544.x
Subject(s) - medicine , blood pressure , tracking (education) , meta analysis , intervention (counseling) , clinical trial , pediatrics , cardiology , psychiatry , psychology , pedagogy
Aim: Blood pressure (BP) is related with cardiovascular disease. BP tracking in childhood and its implication for intervention trials are unknown. Methods: A systematic review and meta‐analysis were conducted to estimate BP tracking. Results: In 29 independent studies on 27 820 subjects, follow‐up length and baseline age were associated with systolic BP tracking (both p < 0.05), while gender, BP measurement method and study place were not (p = 0.215, p = 0.185 and p = 0.391). The overall adjusted systolic BP correlation coefficient was 0.44 between 10 and 11 years and decreased to 0.37 between 10 and 20 years. Comparison of BP changes before and after intervention need a 26% increased sample size for a 10‐year follow‐up of 10 year olds, while trials comparing BP values at study end only require smaller sample sizes. Conclusion: Blood pressure tracking from childhood to adulthood affects trials assessing long‐term effects on BP and was low‐to‐moderate. Therefore, regular BP controls are also needed in children with normal BP measurements possibly identifying hypertensive children earlier. A slight short‐term intervention effect on BP may not have any long‐term effects because of low BP tracking and its decrease by age.