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Metabolic profiles of fat and glucose differ by gender in healthy 8‐year‐olds
Author(s) -
Eriksson Susanne,
Palsdottir Vilborg,
Garemo Malin,
Mellström Dan,
Strandvik Birgitta
Publication year - 2010
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2009.01513.x
Subject(s) - adiponectin , overweight , endocrinology , medicine , leptin , anthropometry , insulin , body mass index , obesity , lean body mass , childhood obesity , metabolic syndrome , insulin resistance , body fat percentage , body weight
Objective: The aim was to investigate if metabolic markers were associated with anthropometry and weight increase in healthy 8‐year‐olds. Methods: Ninety‐seven healthy children, 66 of whom had been examined at the age of 4 years, were investigated. Dual energy X‐ray absorptiometry was performed to determine fat (FM) and lean body mass (LBM). Plasma glucose and serum levels of insulin, cholesterol, triglycerides, adiponectin and leptin were analysed and HOMA‐indices were calculated. Results: Despite similar anthropometry, metabolic markers differed by gender. Sixteen % of the children were overweight or obese. Body mass index (BMI) was strongly correlated to FM. Anthropometric measures except LBM correlated to metabolic markers in the girls. Boys had higher concentrations of plasma glucose than girls. In overweight children, insulin was negatively associated with LBM. Leptin and the ratio between leptin and adiponectin, but not adiponectin, were significantly associated with HOMA‐IR and body composition. Conclusion: The metabolic profile of plasma glucose, serum leptin, fasting insulin and related HOMA indices differed by gender, despite no difference in BMI or FM. LBM, but not FM correlated to the insulin concentration in the overweight children. Leptin was the best marker of overweight.