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Temporal alterations in brain water diffusivity in neonatal meningitis
Author(s) -
Malik Gyanendra K,
Yadav Abhishek,
Trivedi Richa,
Srivastava Arti,
Prasad Kashi N,
Gupta Rakesh K
Publication year - 2009
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2009.01353.x
Subject(s) - medicine , effective diffusion coefficient , diffusion mri , magnetic resonance imaging , white matter , abnormality , meningitis , bayley scales of infant development , nuclear medicine , parenchyma , radiology , pediatrics , pathology , psychomotor learning , psychiatry , cognition
Abstract Aim: To compare changes in apparent diffusion coefficient (ADC) in neonatal meningitis using serial diffusion‐weighted imaging (DWI). Method: Thirty neonates with meningitis and 12 age/sex‐matched controls were studied using DWI. ADC was quantified by placing region of interest(s) on periventricular white matter during acute illness and again at 21 days. Three groups of patients were studied: those with normal findings on both conventional MRI and DWI, those with abnormal DWI only and those with abnormal conventional MRI as well as DWI. Neurodevelopment assessment was performed in controls and patients at 3 months using Indian adaptation of Bayley scales of infant development (BSID) kit. Results: Patients with neonatal meningitis with normal imaging (n = 8) showed no significant difference in ADC compared to controls. Patients showing abnormality only on DWI (n = 10) and on both conventional magnetic resonance imaging (MRI) as well as DWI (n = 12) had significantly reduced ADC (p = 0.001) than controls at baseline study. Follow‐up study showed no significant differences in ADC in controls compared to any patient group. Significantly reduced neurodevelopmental scores were observed in patient groups compared to controls. Conclusion: We conclude that quantitative ADC may detect meningitis‐induced hypoxia early in brain parenchyma, which may be associated with abnormal motor and mental development.